國家衛生研究院 NHRI:Item 3990099045/7549
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    題名: Clinical decision-making for vitamin K-1 and K-2 deficiency and coronary artery calcification with warfarin therapy: Are diet, factor Xa inhibitors or both the answer?
    其他題名: 維生素K拮抗劑治療而致維生素K-1和K-2缺乏及冠狀動脈鈣化的臨床決策：飲食、第十凝血因子抑制劑或者兩者是解答嗎？
    作者: Wahlqvist, ML;Tanaka, K;Tzeng, BH
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Coronary artery calcification is a recognised risk factor for ischaemic heart disease and mortality. Evidence is now strong that M?nckeberg's arteriosclerosis, a form of vascular calcification, can be attributable to vitamin K deficiency, but that vitamin K-2, especially the MK-4 form from foods like cheese can be protective. Warfarin blocks the recycling of hepatic and peripheral vitamin K leading to secondary vitamin K deficiency with adverse effects on vasculature, bone, kidneys, brain and other tissues and systems (inflammatory, immune function and neoplasia at least). There is individual susceptibility to vitamin K deficiency and warfarin sensitivity, partly explicable in terms of genetic polymorphisms, epigenetics, diet and pharmacotherapy. The emergence of extensive coronary calcification in a man with atrial fibrillation treated for a decade with warfarin is described by way of illustration and to raise the present clinical management conundrums. Finally, a putative set of recommendations is provided.
    日期: 2013-08
    關聯: Asia Pacific Journal of Clinical Nutrition. 2013 Aug;22(3):492-496.
    Link to: http://dx.doi.org/10.6133/apjcn.2013.22.3.21
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-7058&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000323796900020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84883777898
    顯示於類別:[MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文

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