國家衛生研究院 NHRI:Item 3990099045/7511
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    題名: BPR0C305, an orally active microtubule-disrupting anticancer agent
    作者: Li, WT;Yeh, TK;Song, JS;Yang, YN;Chen, TW;Lin, CH;Chen, CP;Shen, CC;Hsieh, CC;Lin, HL;Chao, YS;Chen, CT
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: BPR0C305 is a novel N-substituted indolyl glyoxylamide previously reported with in-vitro cytotoxic activity against a panel of human cancer cells including P-gp-expressing multiple drug-resistant cell sublines. The present study further examined the underlying molecular mechanism of anticancer action and evaluated the in-vivo antitumor activities of BPR0C305. BPR0C305 is a novel synthetic small indole derivative that demonstrates in-vitro activities against human cancer cell growth by inhibiting tubulin polymerization, disrupting cellular microtubule assembly, and causing cell cycle arrest at the G2/M phase. It is also orally active against leukemia and solid tumor growths in mouse models. Findings of these pharmacological and pharmacokinetic studies suggest that BPR0C305 is a promising lead compound for further preclinical developments.
    日期: 2013-11
    關聯: Anticancer Drugs. 2013 Nov;24(10):1047-1057.
    Link to: http://dx.doi.org/10.1097/cad.0000000000000014
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-4973&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000325427500007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885386606
    顯示於類別:[葉燈光] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳炯東] 期刊論文

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