國家衛生研究院 NHRI:Item 3990099045/7461
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7461


    Title: Runs of homozygosity associated with speech delay in autism in a Taiwanese Han population: Evidence for the recessive model
    Authors: Lin, PI;Kuo, PH;Chen, CH;Wu, JY;Gau, SSF;Wu, YY;Liu, SK
    Contributors: Center for Neuropsychiatric Research
    Abstract: Runs of homozygosity (ROH) may play a role in complex diseases. In the current study, we aimed to test if ROHs are linked to the risk of autism and related language impairment. We analyzed 546,080 SNPs in 315 Han Chinese affected with autism and 1,115 controls. ROH was defined as an extended homozygous haplotype spanning at least 500 kb. Relative extended haplotype homozygosity (REHH) for the trait-associated ROH region was calculated to search for the signature of selection sweeps. Totally, we identified 676 ROH regions. An ROH region on 11q22.3 was significantly associated with speech delay (corrected p = 1.73×10−8). This region contains the NPAT and ATM genes associated with ataxia telangiectasia characterized by language impairment; the CUL5 (culin 5) gene in the same region may modulate the neuronal migration process related to language functions. These three genes are highly expressed in the cerebellum. No evidence for recent positive selection was detected on the core haplotypes in this region. The same ROH region was also nominally significantly associated with speech delay in another independent sample (p = 0.037; combinatorial analysis Stouffer’s z trend = 0.0005). Taken together, our findings suggest that extended recessive loci on 11q22.3 may play a role in language impairment in autism. More research is warranted to investigate if these genes influence speech pathology by perturbing cerebellar functions.
    Date: 2013-08
    Relation: PLoS ONE. 2013 Aug;8(8):Article number e72056.
    Link to: http://dx.doi.org/10.1371/journal.pone.0072056
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000323570200054
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84881599818
    Appears in Collections:[Chia-Hsiang Chen(2009-2013)] Periodical Articles

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