國家衛生研究院 NHRI:Item 3990099045/7438
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    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/7438


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    题名: Expression of cyclin-dependent kinase 2-associated protein 1 confers an independent prognosticator in nasopharyngeal carcinoma: A cohort study
    作者: Wu, LC;Chen, YL;Wu, WR;Li, CF;Huang, HY;Lee, SW;Chang, SL;Lin, CY;Chen, YH;Hsu, HP;Lu, PJ;Shiue, YL
    贡献者: National Institute of Cancer Research
    摘要: Background and aim Low expression of cyclin-dependent kinase 2-associated protein (CDK2AP1) is associated with tumour progression in oral and oesophageal carcinomas, but is not well studied in patients with head and neck cancer and nasopharyngeal carcinoma (NPC). Methods A rabbit anti-human CDK2AP1 polyclonal antibody was prepared. Immunoblotting of CDK2AP1 was examined in three cell lines and immunoexpression was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. Results Higher CDK2AP1 expression level was identified in dysplastic oral keratinocytes, compared with two NPC-derived HONE-1 and TW01 cell lines. Low expression of CDK2AP1 (50.8%) was correlated with advanced nodal status (p = 0.002) and American Joint Committee on Cancer (AJCC) stage (p = 0.004). In multivariate analyses, low CDK2AP1 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p = 0.037) and local recurrence-free survival (LRFS; p = 0.042), along with AJCC stage IIIeIV (p = 0.034, DSS; p = 0.029, LRFS). Conclusions Low CDK2AP1 expression is common and associated with adverse prognosticators, conferring tumour aggressiveness through cycle cycle, cell growth or apoptosis cellular processes.
    日期: 2012-09
    關聯: Journal of Clinical Pathology. 2012 Sep;65(9):795-801.
    Link to: http://dx.doi.org/10.1136/jclinpath-2012-200893
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-9746&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308426000004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866102917
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