國家衛生研究院 NHRI:Item 3990099045/7435
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    題名: Adenovirus respiratory infections in Taiwanese children, 2002-2011
    作者: Chi, CY;Wang, SL;Kuo, PH;Tsai, HP;Shen, FC;Wang, SM;Liu, CC;Su, IJ;Wang, JR
    貢獻者: Division of Infectious Diseases
    摘要: Introduction: Adenoviruses are common causes of respiratory tract infections in childrenwith several serotypes directly linked to specific human diseases, but surveillance of these infections is lacking inmost countries. Objectives: This study examined the molecular epidemiology and clinical features of pediatric adenoviral infections in a 10-year period in Taiwan. The clinical spectra of influenza A and B viruses infections are presented for comparison as well. Methods: From Jan 2002 to Dec 2012, virus specimens collected from children with respiratory tract infections were identified. The diagnosis of adenovirus was confirmed by viral isolation, and genotypes were examined by DNA sequencing of the hexon and fiber genes. Results: During the study period, adenoviruses were identified from 126 patients. Children with adenovirus were younger than those with influenza A and B (3.9±2.1 years vs. 5.7±5.0 years, and 6.7±4.2 years, p < 0.05), and had shorter hospital stay (4.8±1.5 days vs. 5.3±4.2 days and 6.0±5.3 days, p < 0.05). Children with adenovirus were more likely to be diagnosed as acute pharyngotonsillitis (47%) and concomitant gastrointestinal upset (23%) than those with influenza A and B (p < 0.05). Nearly all of the children with adenovirus (99%) had fever, lasting for a longer duration compared to those with influenza A and B (5.9±1.9 days vs. 4.1±2.9 days and 4.5±2.9 days, p < 0.05). Forty-four percent of children with adenovirus had high fever over 40°C. Children treated as inpatients were significantly to develop high fever, higher C-reactive protein level, and be prescribed with antibiotics than those treated as outpatients (p < 0.05). The most common serotype identified was serotype 3 (64%). High incident coinfection of adenoviruses was detected (19%), and serotype 3 and 2 was the most common combination (58%). Interestingly, 10 children had repeated adenovirus infections and all were infected with species C first, followed by species B or E. Conclusion: Adenovirus infection is associated with significant respiratory morbidities, especially in young children. Adenovirus serotype 3 is the most common genome type in Taiwan since 2002. Coinfection and repeated infections with different adenovirus serotypes or species deserve further attention for vaccine development.
    日期: 2013-06
    關聯: International Journal of Antimicrobial Agents. 2013 Jun;42(Suppl. 2):S149.
    Link to: http://dx.doi.org/10.1016/S0924-8579(13)70581-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000321447400463
    顯示於類別:[蘇益仁(2002-2015)] 會議論文/會議摘要
    [齊嘉鈺] 會議論文/會議摘要

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