國家衛生研究院 NHRI:Item 3990099045/7413
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    题名: Plasma n-3/n-6 PUFAs interact with FADS2 genetic variations to affect blood cholesterol concentrations in type 2 diabetes
    作者: Huang, MC;Huang, PC;Chung, HF;Hsu, CC
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Single nucleotide polymorphisms (SNPs) of fatty acid desaturase (FADS) and n-3/n-6 polyunsaturated fatty acids (PUFAs) have been linked to decreased risks of cardiovascular diseases. We aimed to examine whether FADS SNPs (rs2072114, rs1535, and rs174546 ) interacted with n-3/n-6 PUFAs status as plasma levels to affect blood lipid profiles in type 2 diabetes. In 2008, we selected 192 diabetic patients without using lipid-lowering drugs from a diabetic (DMIDS) cohort established in Taiwan. After adjusting for confounding factors, FADS2 rs2072114 G-variant correlated significantly with decreased total cholesterol (p-trend=0.015), LDL (p-trend=0.009), and HDL (p-trend=0.007) only in the low (<50 percentile) alpha-linolenic acid (ALA)/linoleic acids (LA) group but not in the high (?50 percentile) ALA/LA group (p for interaction= 0.012, 0.012, and 0.181, respectively). Furthermore, the G-variant was significantly associated with lower total cholesterol (p-trend=0.049) and HDL (p-trend=0.024), and marginally with LDL (p-trend=0.067) in the low n-3 long chain PUFA (LCPUFAs) group (<50 percentile) but not in the high n-3 LCPUFAs (?50 percentile) (p for interaction= 0.170, 0.053, and 0.015, respectively). Genetic variations of FADS2 may interact with n-3/n-6 PUFAs to affect cholesterol metabolisms in type 2 diabetes. Further investigation may be needed with larger sample size in this ethnic population.
    日期: 2013-04
    關聯: FASEB Journal. 2013 Apr;27:Article number 1072.8.
    Link to: http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/1072.8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000319883505247
    显示于类别:[許志成] 會議論文/會議摘要

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