國家衛生研究院 NHRI:Item 3990099045/7402
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7402


    Title: Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
    Authors: Lee, SW;Lin, CY;Tian, YF;Sun, DP;Lin, LC;Chen, LT;Hsing, CH;Huang, CT;Hsu, HP;Huang, HY;Wu, LC;Li, CF;Shiue, YL
    Contributors: National Institute of Cancer Research
    Abstract: Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p = 0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p < 0.001), metastasis-free survival (p < 0.001), and local recurrence-free survival (p = 0.001). High expression of CKS1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin-dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.
    Date: 2014-03
    Relation: APMIS. 2014 Mar;122(3):206-214.
    Link to: http://dx.doi.org/10.1111/apm.12136
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0903-4641&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000331253700005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84893815176
    Appears in Collections:[Li-Tzong Chen] Periodical Articles

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