國家衛生研究院 NHRI:Item 3990099045/7351

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7351

Title:	Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells
Authors:	Lee, SJ;Lee, YZ;Hsu, HY;Chang, HY;Chen, IS;Chao, YS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Natural product sources recently have been applied to discover drugs for being developed to treat cancer, immunosuppressive disorders, resistant bacteria and viruses. In many instances, the disease targeted natural products serve as tools to unravel the cellular molecular targets and pathways in the disease processes and thus facilitate further development. Here, we identified a natural quinone compound that inhibited human kidney glutaminase activity and the cell growth and proliferation of lung carcinoma A549 and hepatoma HepG2 as well as blocked the anchorage-independent colony formation of HepG2. Autophagy but not apoptosis was found in A549 and HepG2 cells treated with the natural quinone compound. Further investigation demonstrated the natural quinone compound inhibiting glutaminase activity and conceivably depleting the cellular nutrient and energy to induce autophagy for anti-cancer activity.
Date:	2013-04
Relation:	FASEB Journal. 2013 Apr;27:lb70.
Link to:	http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/lb70
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000319883503140
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract [Yu-Sheng Chao(2002-2013)] Conference Papers/Meeting Abstract

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