國家衛生研究院 NHRI:Item 3990099045/7343
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    題名: CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions
    作者: Kuo, HW;Liu, SC;Tsou, HH;Liu, SW;Lin, KM;Lu, SC;Hsiao, MC;Hsiao, CF;Liu, CY;Chen, CH;Lu, ML;Shen, WW;Tang, HS;Liu, SI;Chang, LH;Wu, HY;Chang, YS;Yeh, TK;Chen, AC;Liu, YL
    貢獻者: Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics;Center for Neuropsychiatric Research;Institute of Biotechnology and Pharmaceutical Research
    摘要: Aim: The liver CYP1A2 enzyme may metabolize antidepressant escitalopram (S-CIT) to S-desmethylcitalopram (S-DCIT) and S-didesmethylcitalopram (S-DDCIT). This study tested whether genetic polymorphisms in the CYP1A2 gene are associated with the treatment responses to S-CIT. Materials & methods: Ten SNPs in CYP1A2 were selected and genotyped in 158 patients under S-CIT treatment. The serum levels of S-CIT and its metabolites were measured by HPLC. Results:CYP1A2 SNPs rs2069521, rs2069526, rs4646425 and rs4646427 are significantly associated with the metabolic ratios of S-DDCIT/S-DCIT (p = 0.002, 0.018, 0.008 and 0.004, respectively) at week 2 of treatment. Carriers of the allele types associated with higher S-DDCIT/S-DCIT ratios had more severe side effects. Conclusion: These results suggest that genetic variants in CYP1A2 may be indicators for S-CIT metabolism and that the fast metabolizers may experience more severe adverse reactions in the early stages of S-CIT treatment.
    日期: 2013-07
    關聯: Pharmacogenomics. 2013 Jul;14(10):1191-1201.
    Link to: http://dx.doi.org/10.2217/pgs.13.105
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1462-2416&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000330375800014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880485709
    顯示於類別:[鄒小蕙] 期刊論文
    [蕭金福] 期刊論文
    [林克明(2004-2009)] 期刊論文
    [劉玉麗] 期刊論文
    [葉燈光] 期刊論文

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