國家衛生研究院 NHRI:Item 3990099045/7317
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    题名: Oral hygiene and risk of head and neck cancer
    作者: Chang, J;Hsiao, JR;Ou, CY;Lo, HI;Huang, CC;Lee, WT;Huang, JS;Chen, KC;Wong, TY;Tsai, ST;Yen, CJ;Wu, YH;Hsueh, WT;Yang, MW;Wu, SY;Chang, JY;Chang, KY;Wang, YH;Weng, YL;Yang, HC;Lin, CL;Wang, FT
    贡献者: National Institute of Cancer Research
    摘要: Previous studies suggested that poor oral hygiene contributes to the development of head and neck cancer (HNC), although the results have been inconsistent. The current analysis examines the association between oral hygiene and HNC and whether this association is modified by the consumption of alcohol, betel quid, or cigarette and by the genetic polymorphisms of inflammationrelated genes. Three hundred seventeen HNC cases and 298 controls were recruited from the department of otolaryngology. Interviews were conducted to ascertain information on dental care practice. Genotyping was performed for 6 single nucleotide polymorphisms in IL6, IL10 and PTGS2. The analysis showed that HNC risk was increased among those without regular dental visits (odds ratio (OR) = 2.9, 95% confidence interval (CI): 1.49-5.63) and those who brush teeth less than twice a day (OR = 1.51, 95% CI: 1.02-2.22). Combining regular dental visits, teeth brushing, and use of dental floss and mouthwash into a dental care score (range: 0-4, 4 = worst dental care), every 1 point increment of dental care score was associated with 1.6 times increase in HNC risk (OR = 1.61, 95% CI: 1.26-2.07). A significant positive association between dental care score and HNC was observed among regular alcohol drinkers (OR = 1.94, 95% CI: 1.40-2.69) but not among never or occasional drinkers (OR = 1.34, 95% CI: 0.90-2.02) (interaction P = 0.02). Multifactor dimensionality reduction analysis divided the study subjects into high- and low-risk group based on combinations of dental care score and IL6 rs1800796 genotypes. Compared to the low-risk group, the high-risk group had an OR of HNC = 2.18 (95% CI: 1.45-3.26). The current study observed a significant positive association between poor oral hygiene and HNC risk, which can be modified by alcohol drinking and the genetic polymorphism of IL6.
    日期: 2013-06
    關聯: American Journal of Epidemiology. 2013 Jun;177(Suppl. 11):S58.
    Link to: http://dx.doi.org/10.1093/aje/kwt103
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9262&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000319870300231
    显示于类别:[張書銘] 會議論文/會議摘要
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