國家衛生研究院 NHRI:Item 3990099045/7306

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Title:	Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan
Authors:	Chang, TP;Ho, MW;Yang, YL;Lo, PC;Lin, PS;Wang, AH;Lo, HJ
Contributors:	Division of Infectious Diseases;Division of Biostatistics and Bioinformatics
Abstract:	Invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. To investigate the distribution and drug susceptibilities of such infections, we analyzed all 152 Candida isolates causing candidemia from 2004 to 2006 at the China Medical University Hospital, a medical center in central Taiwan. Candida albicans was the most common species, accounting for 52.6 % of the isolates, followed by C. tropicalis (19.7 %), C. parapsilosis (14.5 %), C. glabrata (8.6 %), C. guilliermondii (3.9 %), and C. pelliculosa (0.7 %). All isolates were susceptible to amphotericin B, anidulafungin, micafungin, and voriconazole according to minimum inhibitory concentrations (MICs) after a 24-h incubation; 0.7 %, 6.6 %, and 7.9 % of isolates were resistant to amphotericin B, fluconazole, and voriconazole, respectively, after 48-h incubation. Both C. albicans and C. parapsilosis had high degrees of agreement for azoles between 24- and 48-h incubation periods, whereas C. glabrata (38.5–46.2 %) and C. tropicalis (56.7–63.3 %) did not. The majority of the isolates with high azole MICs displayed a trailing growth phenotype. Hence, the MICs of different drugs after 24-h incubation may be considered for prognosis of candidemia.
Date:	2013-12
Relation:	Journal of Infection and Chemotherapy. 2013 Dec;19(6):1065-1071.
Link to:	http://dx.doi.org/10.1007/s10156-013-0623-8
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1341-321X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000328287100008
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890857142
Appears in Collections:	[Hsiu-Jung Lo] Periodical Articles [Pei-Sheng Lin] Periodical Articles

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