國家衛生研究院 NHRI:Item 3990099045/7256
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    题名: Human immunodeficiency virus drug development assisted with AlGaN/GaN high electron mobility transistors and binding-site models
    作者: Kang, YW;Lee, GY;Chyi, JI;Hsu, CP;Hsu, YR;Hsu, CH;Huang, YF;Sun, YC;Chen, CC;Chun Hung, S;Ren, F;Andrew Yeh, J;Wang, YL
    贡献者: Division of Medical Engineering Research
    摘要: Human immunodeficiency virus (HIV) Reverse Transcriptase (RT)-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) and binding-site models were used to find out the dissociation constants of the HIV RT-inhibitor complex and the number of the binding sites on RT for the inhibitor, Efavirenz. One binding site on the RT for the inhibitor is predicted and the dissociation constant extracted from the binding-site model is 0.212 nM. The AlGaN/GaN HEMTs and the binding-site-models are demonstrated to be good tools to assist drug developments by elucidating the dissociation constants and the number of binding sites, which can largely reduce the cost and time for drug developments.
    日期: 2013-05
    關聯: Applied Physics Letters. 2013 May;102(17):Article number 173704.
    Link to: http://dx.doi.org/10.1063/1.4803916
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0003-6951&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000318553000078
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877259626
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