國家衛生研究院 NHRI:Item 3990099045/7252
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    題名: Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery
    作者: Yang, YH;Liu, CH;Liang, YH;Lin, FH;Wu, KCW
    貢獻者: Division of Medical Engineering Research
    摘要: Biocompatible and biodegradable hydroxyapatite nanoparticles with a hollow core and mesoporous shell structure (denoted as hmHANPs) are synthesized by an opposite ion core/shell strategy and applied to pH-responsive intracellular drug delivery systems (DDS). The synthesized hmHANPs have several advantages over solid hydroxyapatite nanoparticles (HANPs), where the hollow and mesoporous structure enhances drug-loading capacity, and the thin hydroxyapatite shell structure reduces burst release of drug and provides pH-responsive release. Doxorubicin (DOX), a therapeutic anticancer drug, was loaded in hmHANPs and HANPs for intracellular drug delivery systems (DDS). Compared to HANPs having a low drug-loading efficacy (17.9%), hmHANPs exhibited an excellent drug-loading efficacy (93.7%). In addition, the release amount of DOX from hmHANPs was 2.5-fold the amount from HANPs. Compared with free DOX, the anticancer efficacy of DOX-loaded hmHANPs was greatly enhanced, as evidenced by the results of MTT assays and confocal laser scanning microscopy using breast cancer cells (BT-20). The synthesized hmHANPs show great potential as drug nanovehicles with high biocompatibility, enhanced drug loading, and pH-responsive features for future intracellular DDS.
    日期: 2013-05
    關聯: Journal of Materials Chemistry B. 2013 May;1(19):2447-2450.
    Link to: http://dx.doi.org/10.1039/c3tb20365d
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000318029600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876894886
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