國家衛生研究院 NHRI:Item 3990099045/7250
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    题名: Honokiol eliminates human oral cancer stem-like cells accompanied with suppression of Wnt/beta-catenin signaling and apoptosis induction
    其它题名: Honokiol eliminates human oral cancer stem-like cells accompanied with suppression of Wnt/β-catenin signaling and apoptosis induction
    作者: Yao, CJ;Lai, GM;Yeh, CT;Lai, MT;Shih, PH;Chao, WJ;Whang-Peng, J;Chuang, SE;Lai, TY
    贡献者: National Institute of Cancer Research
    摘要: Honokiol, an active compound of Magnolia officinalis, exerted many anticancer effects on various types of cancer cells. We explored its effects on the elimination of cancer stem-like side population (SP) cells in human oral squamous cell carcinoma SAS cells. The sorted SP cells possessed much higher expression of stemness genes, such as ABCG2, ABCC5, EpCAM, OCT-4, CD133, CD44, and beta-catenin, and more clonogenicity as compared with the Non-SP cells. After 48 h of treatment, honokiol dose dependently reduced the proportion of SP from 2.53% to 0.09%. Apoptosis of honokiol-treated SP cells was evidenced by increased annexin V staining and cleaved caspase-3 as well as decreased Survivin and Bcl-2. Mechanistically, honokiol inhibited the CD44 and Wnt/beta-catenin signaling of SP cells. The Wnt signaling transducers such as beta-catenin and TCF-4 were decreased in honokiol-treated SP cells, while the beta-catenin degradation promoting kinase GSK-3 alpha/beta was increased. Consistently, the protein levels of beta-catenin downstream targets such as c-Myc and Cyclin D1 were also downregulated. Furthermore, the beta-catenin-related EMT markers such as Slug and Snail were markedly suppressed by honokiol. Our findings indicate honokiol may be able to eliminate oral cancer stem cells through apoptosis induction, suppression of Wnt/beta-catenin signaling, and inhibition of EMT.
    日期: 2013-03
    關聯: Evidence-based Complementary and Alternative Medicine. 2013 Mar;2013:Article number 146136.
    Link to: http://dx.doi.org/10.1155/2013/146136
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317751300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877307280
    显示于类别:[莊雙恩] 期刊論文
    [賴基銘(2004-2008)] 期刊論文

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