國家衛生研究院 NHRI:Item 3990099045/7244
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7244


    Title: Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma
    Authors: Lee, SW;Chen, TJ;Lin, LC;Li, CF;Chen, LT;Hsing, CH;Hsu, HP;Tsai, CJ;Huang, HY;Shiue, YL
    Contributors: National Institute of Cancer Research
    Abstract: Data mining on public domain identified that thymidylate synthetase (TYMS) and dihydrofolate reductase (DHFR) transcripts were significantly higher expressed in nasopharyngeal carcinoma (NPC). In the folate pathway, TYMS catalyzes the methylation of deoxyurdylate to deoxythymidylate using 5,10-methylenetetrahydrofolate [5,10-CH2= THF, derived from tetrahydrofolate (THF)], as a cofactor. This function maintains the thymidine-5-prime monophosphate pool critical for DNA replication and repair and, THF is generated from dihydrofolate (DHF) through the activity of DHFR. Immunoexpression of TYMS and DHFR were retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The outcome was correlated with clinicopathological features and patient survivals. Results indicated that high TYMS (50%) expressions were correlated with primary tumor (p = 0.008) and AJCC stage (p = 0.006), and high DHFR (50%) expression were correlated with nodal status (p = 0.039) and AJCC stage (p = 0.029) (7th American Joint Committee on Cancer), respectively. In multivariate analyses, high TYMS expression emerged as an independent prognosticator for worse disease-specific survival (p < 0.001), distal metastasis-free survival (p = 0.002) and local recurrence-free survival (p < 0.001), along with AJCC stage. Therefore, TYMS expression is common and associated with adverse prognosticators and might confer tumor aggressiveness through dysregulation of the nucleotid biosynthetic process.
    Date: 2013-08
    Relation: Experimental and Molecular Pathology. 2013 Aug;95(1):83-90.
    Link to: http://dx.doi.org/10.1016/j.yexmp.2013.05.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-4800&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000321994000013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84879588410
    Appears in Collections:[Others] Periodical Articles

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