國家衛生研究院 NHRI:Item 3990099045/7148
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 859270      在线人数 : 389
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7148


    题名: Angiomatoid fibrous histiocytoma: Clincopathological and molecular characterization with emphasis on variant histomorphology
    作者: Kao, YC;Lan, J;Tai, HC;Li, CF;Huang, HY
    贡献者: National Institute of Cancer Research
    摘要: Background: Angiomatoid fibrous histiocytoma (AFH) is typified by whirls of plump spindle cells with a triad of pseudoangiomatoid spaces, fibrous pseudocapsules, and lymphocytic cuffs. However, hallmark fusion genes in classical AFH are insufficiently characterized in variant cases. Design: Thirteen AFHs, including 11 with confirmed hallmark translocation, were reappraised for classic features, reactive osteoclasts, mitotic rates, and stromal, architectural, and cytomorphological variations, with CD99, desmin, and EMA stained in available cases. Results: Seven males and 6 females aged from 4 to 63 (median, 13) years, including 3 older than 30 years, had AFHs affecting the extremities (n=6), trunk (n=4), and scalp (n=3). Four showed solid histology devoid of pseudoangiomatoid spaces and another one lacked peripheral lymphoid infiltrates, while fibrous pseudocapsules were observed in each case. Nuclear pleomorphism was striking in 2 cases, moderate in 7, and absent in 4, with osteocalsts seen in 2 cases. In 3 AFHs with sclerotic stroma, one exhibited perivascular hyalinization and nuclear palisading, reminiscent of a schwannoma. In 3 varyingly myxoid tumors, one displayed prominent reticular arrangement of spindle cells in abundant myxoid stroma, resembling a myoepithelioma. Apart from split EWSR1 FISH signals in 4 cases tested, EWSR1-ATF1 fusion was detected in a myoepithelioma-like AFH and EWSR1-CREB1 in another 9, including a schwannoma-like case. Immunohistochemically, 56% of AFHs expressed EMA, 78% desmin, and 100% CD99. Conclusions: Molecular testing can aid in diagnosis of variant AFHs in an awareness of their diverse clinicopathological features.
    日期: 2013-02
    關聯: Laboratory Investigation. 2013 Feb;93(Suppl. 1):14A.
    Link to: http://dx.doi.org/10.1038/labinvest.2013.13
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0023-6837&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000314789300047
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000314789300047.pdf1779KbAdobe PDF559检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈