國家衛生研究院 NHRI:Item 3990099045/7123
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    題名: Activation of the MEK pathway is required for complete scattering of MCF7 cells stimulated with heregulin-Beta1
    其他題名: Activation of the MEK pathway is required for complete scattering of MCF7 cells stimulated with heregulin-β1
    作者: Chang, YT;Shu, CL;Fukui, Y
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Rac1 is important for dissociation of cells during scattering, but whether its activation alone is sufficient to induce complete scattering is not known. To test this, we created an inducible MCF7 cell line that expresses dominant active Rac1. Although induction of dominant active Rac1 resulted in dissociation of cells, their scattering was incomplete. We co-expressed dominant active MKK1a, an activator of ERK, and dominant active Rac1. In this case, cells completely scattered. These results suggest that not only Rac1 but also the MEK1 pathway is required for dissociation and complete scattering of MCF7 cells treated with HRG-β1.
    日期: 2013-04
    關聯: Biochemical and Biophysical Research Communications. 2013 Apr;433(3):311-316.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2013.02.103
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000318190400008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876305160
    顯示於類別:[福井泰久(2010-2016)] 期刊論文

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