國家衛生研究院 NHRI:Item 3990099045/7049
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    題名: A consensus envelope protein domain III can induce neutralizing antibody responses against serotype 2 of dengue virus in non-human primates
    作者: Chen, HW;Liu, SJ;Li, YS;Liu, HH;Tsai, JP;Chiang, CY;Chen, MY;Hwang, CS;Huang, CC;Hu, HM;Chung, HH;Wu, SH;Chong, P;Leng, CH;Pan, CH
    貢獻者: Division of Vaccine Research and Development
    摘要: We have previously demonstrated that vaccination with a subunit dengue vaccine containing a consensus envelope domain III with aluminum phosphate elicits neutralizing antibodies against all four serotypes of dengue virus in mice. In this study, we evaluated the immunogenicity of the subunit dengue vaccine in nonhuman primates. After vaccination, monkeys that received the subunit vaccine with aluminum phosphate developed a significantly strong and long-lasting antibody response. A specific T cell response with cytokine production was also induced, and this correlated with the antibody response. Additionally, neutralizing antibodies against serotype 2 were detected in two of three monkeys. The increase in serotype-2-specific antibody titers and avidity observed in these two monkeys suggested that a serotype-2-biased antibody response occurs. These data provide evidence that a protective neutralizing antibody response was successfully elicited in non-human primates by the dengue subunit vaccine with aluminum phosphate adjuvant.
    日期: 2013-07
    關聯: Archives of Virology. 2013 Jul;158(7):1523-1531.
    Link to: http://dx.doi.org/10.1007/s00705-013-1639-1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-8608&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000321066600009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84879695861
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