國家衛生研究院 NHRI:Item 3990099045/7048
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    題名: Human SCARB2 transgenic mice as an infectious animal model for Enterovirus 71
    作者: Ho, W;Lin, YW;Yu, SL;Shao, HY;Lin, HY;Liu, CC;Hsiao, KN;Chitra, E;Tsou, YL;Chang, HW;Sia, C;Chong, P;Chow, YH
    貢獻者: Division of Vaccine Research and Development
    摘要: Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in children. Lack of a reliable animal model is an issue in investigating EV71-induced disease manifestation in humans, and the current clinical therapies are symptomatic. We generated a novel EV71-infectious model with hSCARB2-transgenic mice expressing the discovered receptor human SCARB2 (hSCARB2). The challenge of hSCARB2-transgenic mice with clinical isolates of EV71 and CVA16 resulted in HFMD-like and neurological syndromes caused by E59 (B4) and N2838 (B5) strains, and lethal paralysis caused by 5746 (C2), N3340 (C4), and CVA16. EV71 viral loads were evident in the tissues and CNS accompanied the upregulated pro-inflammatory mediators (CXCL10, CCL3, TNF-a, and IL-6), correlating to recruitment of the infiltrated T lymphocytes that result in severe diseases. Transgenic mice preimmunized with live E59 or the FI-E59 vaccine was able to resist the subsequent lethal challenge with EV71. These results indicate that hSCARB2-transgenic mice are a useful model for assessing anti-EV71 medications and for studying the pathogenesis induced by EV71.
    日期: 2013-02-25
    關聯: PLoS ONE. 2013 Feb 25;8(2):Article number e57591.
    Link to: http://dx.doi.org/10.1371/journal.pone.0057591
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000316849500117
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874378993
    顯示於類別:[周彥宏] 期刊論文
    [謝鐸源(2006-2014)] 期刊論文
    [劉家齊] 期刊論文
    [莊再成] 期刊論文

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