國家衛生研究院 NHRI:Item 3990099045/6981
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6981


    Title: Gender, Body Mass Index, and PPAR gamma Polymorphism Are Good Indicators in Hyperuricemia Prediction for Han Chinese
    Other Titles: Gender, body mass index, and PPARγ polymorphism are good indicators in hyperuricemia prediction for han Chinese
    Authors: Lee, MF;Liou, TH;Wang, W;Pan, WH;Lee, WJ;Hsu, CT;Wu, SF;Chen, HH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Hyperuricemia is closely associated with obesity and metabolic abnormalities, which is also an independent risk factor for cardiovascular diseases. The PPARγ gene, which is linked to obesity and metabolic abnormalities in Han Chinese, might be considered a top candidate gene that is involved in hyperuricemia. This study recruited 457 participants, aged 20-40 years old, to investigate the associations of the PPARγ gene and metabolic parameters with hyperuricemia. Three tag-single nucleotide polymorphisms, rs2292101, rs4684846, and rs1822825, of the PPARγ gene were selected to explore their association with hyperuricemia. Risk genotypes on rs1822825 of the PPARγ gene exhibited statistical significance with hyperuricemia (odds ratio: 1.9; 95% confidence interval: 1.05-3.57). Although gender, body mass index (BMI), serum total cholesterol concentration, or protein intake per day were statistically associated with hyperuricemia, the combination of BMI, gender, and rs1822825, rather than that of age, serum lipid profile, blood pressure, and protein intake per day, satisfied the predictability for hyperuricemia (sensitivity: 69.3%; specificity: 83.7%) in Taiwan-born obese Han Chinese. BMI, gender, and the rs1822825 polymorphism in the PPARγ gene appeared good biomarkers in hyperuricemia; therefore, these powerful indicators may be included in the prediction of hyperuricemia to increase the accuracy of the analysis.
    Date: 2013-12-13
    Relation: Genetic Testing and Molecular Biomarkers. 2013 Dec 13;17(1):40-46.
    Link to: http://dx.doi.org/10.1089/gtmb.2012.0231
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1945-0265&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000312494900009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871264232
    Appears in Collections:[Wen-Harn Pan] Periodical Articles

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