國家衛生研究院 NHRI:Item 3990099045/6966
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    题名: Antimigratory effects of the methanol extract from Momordica charantia on human lung adenocarcinoma CL1 cells
    作者: Hsu, HY;Lin, JH;Li, CJ;Tsang, SF;Tsai, CH;Chyuan, JH;Chiu, SJ;Chuang, SE
    贡献者: National Institute of Cancer Research
    摘要: Momordica charantia has been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract of Momordica charantia (MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt, β-catenin, and MMPs.
    日期: 2012-12
    關聯: Evidence-based Complementary and Alternative Medicine. 2012 Dec;2012:Article ID 819632.
    Link to: http://dx.doi.org/10.1155/2012/819632
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-3592&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000312863400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872138701
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