國家衛生研究院 NHRI:Item 3990099045/6891
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    題名: CD4 T-cell-independent antibody response reduces Enterovirus 71 lethality in mice by decreasing tissue viral loads
    作者: Wang, LC;Kao, CM;Ling, P;Su, IJ;Chang, TM;Chen, SH
    貢獻者: Division of Infectious Diseases
    摘要: Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deficient in CD4(+) T cells were resistant to EV71 infection as wild-type mice, whereas mice deficient in B cells were highly susceptible to viral infection. Compensation of CD4 T-cell function by other immune cells was not likely, because wild-type mice depleted of CD4(+) T cells were also resistant to viral infection. Infected CD4 T-cell-deficient mice produced virus-specific neutralizing antibodies, IgM and IgG. Moreover, adoptive transfer of the virus-specific antibody produced by infected CD4 T-cell-deficient mice protected B-cell-deficient mice from infection by reducing tissue viral loads. Collectively, our results show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice and suggest great potential for the use of vaccines and neutralizing antibodies to reduce fatal symptoms in patients.
    日期: 2012-11
    關聯: Clinical and Developmental Immunology. 2012 Nov;2012:Article ID 580696.
    Link to: http://dx.doi.org/10.1155/2012/580696
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000310635400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870169234
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文

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