國家衛生研究院 NHRI:Item 3990099045/6874
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 925079      線上人數 : 935
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6874


    題名: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    作者: Lan, Q;Hsiung, CA;Matsuo, K;Hong, YC;Seow, A;Wang, Z;Hosgood, HD;Chen, K;Wang, JC;Chatterjee, N;Hu, W;Wong, MP;Zheng, W;Caporaso, N;Park, JY;Chen, CJ;Kim, YH;Kim, YT;Landi, MT;Shen, H;Lawrence, C;Burdett, L;Yeager, M;Yuenger, J;Jacobs, KB;Chang, IS;Mitsudomi, T;Kim, HN;Chang, GC;Bassig, BA;Tucker, M;Wei, F;Yin, Z;Wu, C;An, SJ;Qian, B;Lee, VHF;Lu, D;Liu, J;Jeon, HS;Hsiao, CF;Sung, JS;Kim, JH;Gao, Y-T;Tsai, YH;Jung, YJ;Guo, H;Hu, Z;Hutchinson, A;Wang, WC;Klein, R;Chung, CC;Oh, IJ;Chen, KY;Berndt, SI;He, X;Wu, W;Chang, J;Zhang, XC;Huang, MS;Zheng, H;Wang, J;Zhao, X;Li, Y;Choi, JE;Su, WC;Park, KH;Sung, SW;Shu, XO;Chen, YM;Liu, L;Kang, CH;Hu, L;Chen, CH;Pao, W;Kim, YC;Yang, TY;Xu, J;Guan, P;Tan, W;Su, J;Wang, CL;Li, H;Sihoe, ADL;Zhao, Z;Chen, Y;Choi, YY;Hung, JY;Kim, JS;Yoon, HI;Cai, Q;Lin, CC;Park, IK;Xu, P;Dong, J;Kim, C;He, Q;Perng, RP;Kohno, T;Kweon, S;et al.
    貢獻者: Division of Biostatistics and Bioinformatics;National Institute of Cancer Research
    摘要: To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10−6) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10−18), 6q22.2 (rs9387478, P = 4.14 × 10−10) and 6p21.32 (rs2395185, P = 9.51 × 10−9). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.
    日期: 2012-11
    關聯: Nature Genetics. 2012 Nov;44(12):1330-1335.
    Link to: http://dx.doi.org/10.1038/ng.2456
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1061-4036&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000311713200011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870502715
    顯示於類別:[熊昭] 期刊論文
    [蕭金福] 期刊論文
    [張憶壽] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    NHD2012112003.pdf624KbAdobe PDF740檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋