國家衛生研究院 NHRI:Item 3990099045/6857
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    題名: Hysterectomy with ovarian conservation in young women associates with higher cardiovascular risk: A nationwide cohort study
    作者: Yeh, JS;Cheng, HM;Hsu, PF;Sung, SH;Chuang, SY
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Objectives: We aimed to investigate the exact influence of hysterectomy with ovarian conservation on the risk of cardiovascular events, with adjustment for traditional risk factors. Background: Hysterectomy is a common procedure for treatment of numerous gynecologic diseases. However, its association with the risk of cardiovascular events remains controversial. Methods: A nationwide population-based study using the Taiwan National Health Insurance database fromthe 1million sampling cohort data set was conducted. A total of 8059 women who underwent hysterectomy with ovarian conservation during 1997 to 2009 were identified. The control group consisted of 32,236 women without hysterectomy by matching age at operation, hypertension, diabetes, dyslipidemia and surgery date. Results: A total of 806 strokes, 986 coronary heart diseases (CHD), and 1055 cardiovascular diseases (CVD) developed during a median 6.97 years follow-up. The difference was not significant between women with and without hysterectomy for CHD (3.37 vs. 3.06 per 1000 person-year, p = 0.23), stroke (3.17 vs. 2.87, p =0.28) and CVD (4.27 vs. 3.79, p = 0.14). However, of the women who underwent hysterectomy with before 45 years, the hazard ratio of hysterectomy was 1.95 (1.40-2.72) for stroke and 1.60 (1.20-2.12) for cardiovascular events. Conclusions: The association between hysterectomy and the risk of cardiovascular disease was different according to the patients’ age at operation. The excess risk of cardiovascular events, mainly driven by the development of stroke, was observed in women had hysterectomy with ovary conservation before 45 years and remained significant even after accounting for baseline cardiovascular risk factors.
    日期: 2012-08
    關聯: European Heart Journal. 2012 Aug;33(Suppl. 1):125.
    Link to: http://dx.doi.org/10.1093/eurheartj/ehs281
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308012401399
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