國家衛生研究院 NHRI:Item 3990099045/6818
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 909681      Online Users : 808
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6818


    Title: TLR9-mediated ARF6 activation is involved in advancing CpG ODN cellular uptake
    Authors: Wu, JY;Kuo, CC
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Nucleic acid cellular uptake into endosomes is critical in eliciting nucleotide-sensing toll-like receptors (TLRs) innate immune responses. ADP-ribosylation factor 6 (ARF6) is a member of the Ras superfamily, which is critical to a wide variety of cellular events including endocytosis. Our previous report indicated that ARF6 plays a critical role in CpG ODN/TLR9-mediated responses. Here, we further explored that the basal level of active ARF6 is nonspecifically responsible for initiation of ODNs uptake, which is relatively CpG motif independent. While the initiation of CpG ODN uptake but not GpC ODN uptake can promote TLR9 responses thereby enhancing ARF6 activation which may lead to further nonspecifically increase of cellular uptake of stimulatory CpG ODN as well as nonstimulatory GpC ODN. Because nucleotide-sensing TLR9 plays a role in contributing to immune diseases, selective activation or inhibition of ARF6 might be useful in certain immunological or therapeutic applications.
    Date: 2012-07
    Relation: Communicative and Integrative Biology. 2012 Jul;5(4):316-318.
    Link to: http://dx.doi.org/10.4161/cib.20182
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84869831987
    Appears in Collections:[Cheng-Chin Kuo] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    PUB23060951.pdf395KbAdobe PDF490View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback