國家衛生研究院 NHRI:Item 3990099045/6783
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6783


    Title: Ameliorative effects of scopoletin from Crossostephium chinensis against inflammation pain and its mechanisms in mice
    Authors: Chang, TN;Deng, JS;Chang, YC;Lee, CY;Jung Chun, L;Lee, MM;Peng, WH;Huang, SS;Huang, GJ
    Contributors: National Institute of Cancer Research
    Abstract: Scopoletin exists in nature as an anti-oxidant, hepatoprotective, and anti-inflammatory activities reagent. In this study, we have investigated the analgesic effects of the scopoletin using the models of acetic acid-induced writhing response and the formalin test, the anti-inflammatory effects of scopoletin using model of lambda-carrageenan (Carr)-induced paw edema. The treatment of ICR mice with scopoletin inhibited the numbers of writhing response and the formalin-induced pain in the late phase. This study demonstrated that the administration of scopoletin resulted in the reduction of Carr-induced mice edema, and it increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) after Carr injection. We also demonstrated scopoletin significantly attenuated the malondialdehyde (MDA) level in the edema paw after Carr injection. Scopoletin decreased the NO, tumor necrosis factor (TNF-alpha) and prostaglandin E2 (PGE(2)) levels on serum after Carr injection. Scopoletin decreased Carr-induced inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in the edema paw. These anti-inflammatory mechanisms of scopoletin might be related to the decrease in the level of MDA via increasing the activities of SOD, CAT, and GPx in the edema paw. Also, scopoletin could affect the production of NO, TNF-alpha, and PGE(2), and therefore affect the anti-inflammatory effects.
    Date: 2012-09
    Relation: Evidence-based Complementary and Alternative Medicine. 2012 Sep;2012:Article ID 595603.
    Link to: http://dx.doi.org/10.1155/2012/595603
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308765900001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867019397
    Appears in Collections:[Others] Periodical Articles

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