國家衛生研究院 NHRI:Item 3990099045/6749
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911383      在线人数 : 947
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6749


    题名: Dissemination of multidrug-resistant Acinetobacter baumannii carrying BlaOxA-23 from hospitals in central Taiwan
    作者: Lee, MH;Chen, TL;Lee, YT;Huang, L;Kuo, SC;Yu, KW;Hsueh, PR;Dou, HY;Su, IJ;Fung, CP
    贡献者: Division of Infectious Diseases
    摘要: Background: Imipenem-resistant Acinetobacter baumannii (IRAB) poses a great threat to healthcare systems. Production of carbapenem-hydrolyzing class D b-lactamases (CHDLs) is the major mechanism for imipenem resistance. In this study, we found a high prevalence of IRAB carrying a gene encoding CHDL, blaOxA-23, in central Taiwan and elucidated the molecular characteristics and possible mechanisms of the spread of these isolates. Methods: During 2007, we collected 291 nonrepetitive A baumannii isolates from 10 teaching hospitals in Taiwan. The antimicrobial susceptibility of the isolates was determined by agar dilution or Etest. The genes encoding carbapenemase and related structure were detected by polymerase chain reaction mapping and sequencing, and the clonal relationship of the isolates was analyzed by pulsed-field gel electrophoresis. Plasmid localization of blaOxA-23 was determined by extraction of plasmid with commercial kit and Southern blot analysis. Results: Among 142 IRAB isolates, 30 harbored the blaOxA-23. The prevalence of IRAB with blaOxA-23 was highest in central Taiwan compared to other areas [24.8% (27/109) vs. 1.6% (3/182); p < 0.001]. These IRAB with blaOxA-23 were also resistant to other antimicrobial agents, except colistin. The PCR methods showed the presence of blaOxA-51 in all isolates.
    日期: 2013-12
    關聯: Journal of Microbiology, Immunology and Infection. 2013 Dec;46(6):419-424.
    Link to: http://dx.doi.org/10.1016/j.jmii.2012.08.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000329598800003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890126531
    显示于类别:[蘇益仁(2002-2015)] 期刊論文
    [杜鴻運] 期刊論文
    [郭書辰] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO2012100110.pdf674KbAdobe PDF672检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈