國家衛生研究院 NHRI:Item 3990099045/6735
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911491      在线人数 : 922
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6735


    题名: Regulation of PKC-theta function by phosphorylation in T cell receptor signaling
    其它题名: Regulation of PKC-θ function by phosphorylation in T cell receptor signaling
    作者: Wang, X;Chuang, HC;Li, JP;Tan, TH
    贡献者: Immunology Research Center
    摘要: Protein kinase C (PKC)-θ is a serine/threonine kinase belonging to the calcium-independent novel PKC subfamily; its expression is restricted to certain tissues and cell types, including T cells. The signals delivered from T cell receptor (TCR) and CD28 costimulatory molecules trigger PKC-θ catalytic activation and membrane translocation to the immune logical synapse, leading to activation of NF-κB, AP-1, and NF-AT.These transcription factors are important forT cell survival, activation, and differentiation. Phosphorylation of PKC-θ at multiple Ser/Thr/Tyr residues is induced inT cells duringTCR signaling. Some phosphorylation sites play critical roles in the regulation of PKC-θ function and downstream signaling. The regulation mechanisms for PKC-θ phosphorylation sites are now being revealed. In this review, we discuss the current understanding of the regulation of PKC-θ function by phosphorylation duringTCR signaling.
    日期: 2012-07
    關聯: Frontiers in Immunology. 2012 Jul;3:Article number 197.
    Link to: http://dx.doi.org/10.3389/fimmu.2012.00197
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000209501300193
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874219989
    显示于类别:[譚澤華] 期刊論文
    [莊懷佳] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    NIM2012092501.pdf1716KbAdobe PDF750检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈