國家衛生研究院 NHRI:Item 3990099045/6730
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    题名: Alpha-tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways
    其它题名: α-tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways
    作者: Chao, MW;Chen, CH;Chang, YL;Teng, CM;Pan, SL
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: a-Tomatine, a tomato glycoalkaloid, has been reported to possess antibiotic properties against human pathogens. However,the mechanism of its action against leukemia remains unclear. In this study, the therapeutic potential of a-tomatine againstleukemic cells was evaluated in vitro and in vivo. Cell viability experiments showed that a-tomatine had significant cytotoxic effects on the human leukemia cancer cell lines HL60 and K562, and the cells were found to be in the Annexin V-positive/ propidium iodidenegative phase of cell death. In addition, a-tomatine induced both HL60 and K562 cell apoptosis in a cell cycle- and caspase-independent manner. a-Tomatine exposure led to a loss of the mitochrondrial membrane potential, and this finding was consistent with that observed on activation of the Bak and Mcl-1 short form (Mcl-1s) proteins. Exposure to a-tomatine also triggered the release of the apoptosis-inducing factor (AIF) from the mitochondria into the nucleus and down-regulated survivin expression. Furthermore, a-tomatine significantly inhibited HL60 xenograft tumor growth without causing loss of body weight in severe combined immunodeficiency (SCID) mice. Immunohistochemical test showed that the reduced tumor growth in the a-tomatine-treated mice was a result of increased apoptosis, which was associated with increased translocation of AIF in the nucleus and decreased survivin expression ex vivo. These results suggest that a-tomatine may be a candidate for leukemia treatment.
    日期: 2012-09-06
    關聯: PLoS ONE. 2012 Sep 6;7(9):Article number e44093.
    Link to: http://dx.doi.org/10.1371/journal.pone.0044093
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308458400035
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866099730
    显示于类别:[潘秀玲(2009-2013)] 期刊論文

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