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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/6687
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| Title: | Neonatal cytokine profiles and risk of childhood acute lymphoblastic leukemia |
| Authors: | Chang, JS;Zhou, M;Buffler, PA;Metayer, C;Chokkalingam, AP;Wiemels, JL |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Purpose: Childhood acute lymphoblastic leukemia (ALL) is hypothesized to originate from abnormal immune responses to infectious agents resulting from lack of immune modulation during early childhood. It has been shown that a child's immune development begins in utero, and that a child's baseline immune function at birth may affect his/her response to subsequent infectious exposures. The current study examines the association between neonatal cytokine profiles and childhood ALL. Methods: Neonatal blood spots of 116 childhood ALL cases and 116 controls living in California were ascertained. 11 cytokines associated with Th1, Th2, and Th17 lymphocytes were measured using a multiplex beadbased assay. Unconditional logistic regression was performed to estimate the odds ratio (OR) measuring the association between neonatal cytokines and ALL adjusted for age, sex, race/ethnicity, and household income. Results: Of the 11 cytokines measured, 5 (IL4, IL6, IL10, IL12, and IL13) were detectable. Except for IL12, the other 4 cytokines were all significantly lower among cases compared to controls. In a multivariable model including the 5 cytokines, only IL10 remained independently associated with childhood ALL with an OR=0.04, 95% confidence interval: 0.01–0.18, comparing the highest tertile to the lowest tertile. Conclusion: IL10 is a key regulator for modulating the intensity and duration of immune responses. The current analysis shows that children with ALL may have a dysregulated immune function present at birth. |
| Date: | 2010-09 |
| Relation: | Annals of Epidemiology. 2010 Sep;20(9):693. |
| Link to: | http://dx.doi.org/10.1016/j.annepidem.2010.07.009 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1047-2797&DestApp=IC2JCR |
| Appears in Collections: | [張書銘] 會議論文/會議摘要
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| SDO2012082226.pdf | | 33Kb | Adobe PDF | 482 | View/Open |
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