國家衛生研究院 NHRI:Item 3990099045/6676

NHRI > National Institute of Environmental Health Sciences > Shu-Li Wang > Conference Papers/Meeting Abstract > Item 3990099045/6676

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6676

Title:	Arsenic metabolism, lactate dehydrogenase and electrocardiogram abnormality among residents in the arseniasis-endemic areas of southwestern Taiwan
Authors:	Liao, Y;Chen, C;Chen, W;Li, W;Chen, HY;Wang, SL
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Arsenic is a potent but modifiable environmental pollutant that has been linked to the increasing global prevalence of high-mortality in Cardiovascular Disease (CVD) (Navas-Acien et al. 2005); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro (Petrick et al.2000; Peraza et al. 2003; Saad et al. 2006), but is not validated for the evaluation of long-term, chronic arsenic exposure. Various Electrocardiogram (ECG) abnormalities have been observed among cases of acute arsenic poisoning and individuals exposed to excess arsenic through drinking water (Wang et al. 2007). While both LDH elevation and ECG abnormality were previously used as indicators for acute myocardial infarction in clinical practice, their correlation amongst arsenic-exposed subjects was still unclear. Individual variability in human arsenic metabolism has been reported to be an underlying determinant of individual susceptibility to arsenic-induced disease (U.S. EPA 1988). The present study examines the long-term effect of chronic arsenic exposure on plasma LDH levels and ECG abnormality.
Date:	2012-07
Relation:	Understanding the Geological and Medical Interface of Arsenic- As 2012: Proceedings of the 4th International Congress on Arsenic in the Environment, 22-27 July 2012, Cairns, Australia. 2012 Jul:155-156.
Link to:	http://www.crcnetbase.com/doi/abs/10.1201/b12522-63
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000393139700055
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864866305
Appears in Collections:	[Shu-Li Wang] Conference Papers/Meeting Abstract [Wan-Fen Li(2001-2009)] Conference Papers/Meeting Abstract

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