國家衛生研究院 NHRI:Item 3990099045/6658
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    题名: Challenges to licensure of enterovirus 71 vaccines
    作者: Lee, MS;Tseng, FC;Wang, JR;Chi, CY;Chong, P;Su, IJ
    贡献者: Division of Infectious Diseases;Division of Vaccine Research and Development
    摘要: Human enteroviruses usually cause self-limited infections except polioviruses and enterovirus 71 (EV71), which frequently involve neurological complications. EV71 vaccines are being evaluated in humans. However, several challenges to licensure of EV71 vaccines need to be addressed. Firstly, EV71 and coxsackievirus A (CA) are frequently found to co-circulate and cause hand-foot-mouth disease (HFMD). A polyvalent vaccine that can provide protection against EV71 and prevalent CA are desirable. Secondly, infants are the target population of HFMD vaccines and it would need multi-national efficacy trials to prove clinical protection and speed up the licensure and usage of HFMD vaccines in children. An international network for enterovirus surveillance and clinical trials is urgently needed. Thirdly, EV71 is found to evolve quickly in the past 15 years. Prospective cohort studies are warranted to clarify clinical and epidemiological significances of the antigenic and genetic variations between different EV71 genogroups, which is critical for vaccine design.
    日期: 2012-08-28
    關聯: PLoS Neglected Tropical Diseases. 2012 Aug 28;6(8):Article number e1737.
    Link to: http://dx.doi.org/10.1371/journal.pntd.0001737
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1935-2735&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308497100003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865961485
    显示于类别:[蘇益仁(2002-2015)] 期刊論文
    [齊嘉鈺] 期刊論文
    [曾凡真] 期刊論文
    [李敏西] 期刊論文
    [莊再成] 期刊論文

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