國家衛生研究院 NHRI:Item 3990099045/6648
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    題名: Antiretroviral drug resistance among treatment-naïve HIV-1 patients in southern Taiwan
    其他題名: Antiretroviral drug resistance among treatment-naive HIV-1 patients in southern Taiwan
    作者: Tseng, FC;Wang, SW;Lee, HC;Ko, NY;Wu, CJ;Lin, HH;Ko, WC
    貢獻者: Division of Infectious Diseases
    摘要: Background: Antiretroviral drug resistance can reduce the effectiveness of HIV-1 therapy. Resistance should be examined among the treatment-naïve HIV-1 infected so that optimal drugs therapy can be prescribed. We studied its prevalence and pattern among 101 newly identified HIV-1 patients in southern Taiwan. Methods: HIV-1 RNA from plasma was sequenced for the protease (PR) and reverse transcriptase region, from which the HIV-1 subtype can also be determined. Drug-resistant mutations were examined using the algorithm of the French National Agency for AIDS Research (ANRS). Results: Subtypes were 43 B’, 8 CRF01_AE and 50 CRF07_BC. Averages of two clinical parameters were calculated for each subtype: CD4 counts and HIV copies (in log10) were both the worse among patients with the CRF01_AE and the best in patients with the CRF07_BC (all p < 0.05, t-test). Resistance to 3 categories of drugs was examined: Nucleoside Reverse Transcriptase Inhibitor (NRTI), non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) and Protease Inhibitor (PI); five and nine patients harbored mutations that conferred resistance and possible resistance to at least one drug, respectively. Among the 3 subtypes, B’ had the highest resistance to any drug, 6.4%, followed by CRF07_BC, 4%. When analyzed by 3 drug categories: 1 patient was resistant and 2 were possible resistant to any NRTI; 4 were resistant and 1 was possible resistant to any NNRTI; 1 was resistant and 7 was possible resistant to any PI. When further stratified by subtypes: 2% CRF07_BC was resistant and 4.7% B’ were possible resistant to any NRTI; 4.7% B’ and 4% CRF07_BC were resistant, as well as 2.3% B’ was possible resistant to any NNRTI; 2.3% B’ was resistant, as well as 4.7% B’, 50% CRF01_AE and 2% CRF07_BC were possible resistant to any PI. The 50% “possible resistance” to PI drugs for CRF01_AE was unusually high. Because resistance-mutation definitions in ANRS, including secondary mutations, were mostly based on B subtype, the PR gene of the CRF01_AE could contain polymorphic substitutions that were mis-interpreted as mutations. Conclusion: Among HIV-1 treatment-naïve patients in southern Taiwan, B’ subtype and NNRTIs were associated with higher percentages of drug resistance as compared to other groups. Further in-vitro studies on the PR gene of the CRF01_AE are warranted to clarify roles of the known secondary mutations in this subtype.
    日期: 2012-06
    關聯: International Journal of Infectious Diseases. 2012 Jun;16(Suppl 1):e192.
    Link to: http://dx.doi.org/10.1016/j.ijid.2012.05.762
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308353101084
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