國家衛生研究院 NHRI:Item 3990099045/6585
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    題名: Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon
    作者: Huang, SSY;Strathe, AB;Fadel, JG;Lin, P;Liu, TY;Hung, SSO
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and biomagnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48. h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg. Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48. h post intubation period, and at 48. h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p< 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12. h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg. Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48. h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12. h post intubation.
    日期: 2012-10
    關聯: Aquatic Toxicology. 2012 Oct;122-123:163-171.
    Link to: http://dx.doi.org/10.1016/j.aquatox.2012.06.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0166-445X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308972000019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864034012
    顯示於類別:[林嬪嬪] 期刊論文

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