國家衛生研究院 NHRI:Item 3990099045/6583
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    题名: Statin use and the risk of kidney cancer: A population-based case-control study
    作者: Chiu, HF;Kuo, CC;Kuo, HW;Lee, IM;Lee, CT;Yang, CY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Objective: To investigate whether the use of statins was associated with kidney cancer risk. Methods: We conducted a population-based casecontrol study in Taiwan. Cases consisted of all patients who were aged 50 years and older, and had a first-time diagnosis of kidney cancer for the period between 2005 and 2009. The controls were matched to cases by age, sex, and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multiple logistic regression. Results: We examined 177 kidney cancer cases and 708 controls. The adjusted OR for any statin prescription was 1.08 (95% CI = 0.70 - 1.67). Compared with no use of statins, the adjusted ORs were 0.91 (95% CI = 0.50 - 1.63) for the group having been prescribed statins with cumulative defined daily dose (DDDs) below 105 and 1.28 (95% CI = 0.73 - 2.23) for the group with cumulative statin use of 105 DDDs or more. Conclusions: The present data do not provide evidence to support either beneficial or harmful associations between statin use and kidney cancer risk. However, there is a trend of increased kidney cancer risk with higher cumulative DDDs, and consequently that it is prudent to continue monitoring cancer incidence among long-standing statin users.
    日期: 2012-07
    關聯: Expert Opinion on Drug Safety. 2012 Jul;11(4):543-549.
    Link to: http://dx.doi.org/10.1517/14740338.2012.678831
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1474-0338&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000305701300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862885295
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