國家衛生研究院 NHRI:Item 3990099045/6533
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    题名: Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality
    作者: Huang, T;Chen, Y;Yang, B;Yang, J;Wahlqvist, ML;Li, D
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Background & aims: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. Methods: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. Results: Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. Conclusions: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.
    日期: 2012-08
    關聯: Clinical Nutrition. 2012 Aug;31(4):448-454.
    Link to: http://dx.doi.org/10.1016/j.clnu.2011.01.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0261-5614&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000307419800002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864122121
    显示于类别:[MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文

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