國家衛生研究院 NHRI:Item 3990099045/6490
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6490


    Title: EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
    Authors: Yang, SY;Yang, TY;Li, YJ;Chen, KC;Liao, KM;Hsu, KH;Tsai, CR;Chen, CY;Hsu, CP;Hsia, JY;Chuang, CY;Tsai, YH;Chen, KY;Huang, MS;Su, WC;Chen, YM;Hsiung, CA;Shen, CY;Chang, GC;Yang, PC;Chen, CJ
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: We explored potential associations between genetic polymorphisms in genes related to DNA repair and detoxification metabolism and epidermal growth factor receptor (EGFR) mutations in a cohort of 410 never-smoking patients with lung adenocarcinoma. Multivariate-adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CI) of EGFR mutation status in association with the genotypes of DNA repair and detoxification metabolism genes were evaluated using logistic regression analysis. We found an association between in-frame deletion in EGFR exon 19 and a single nucleotide polymorphism (SNP) rs1800566C/T located in NQO1 (aOR, 2.2 with 95% CI, 1.0–4.8) in female never-smokers. The SNP rs744154C/G in ERCC4 was also associated with the EGFR exon 19 in-frame deletion both in never-smokers (aOR, 1.7 with 95% CI, 1.0-3.0) and female never-smokers (aOR, 1.9 with 95% CI, 1.0-3.6). Although the association was marginally significant in multivariate logistic regression analysis, the A/A genotype of rs1047840 in EXO1 was associated with a 7.6-fold increase in the occurrence of the EGFR exon 19 in-frame deletion in female never-smokers. Moreover, risk alleles in NQO1, ERCC4, and EXO1 were associated with an increasing aOR of the EGFR exon 19 in-frame deletion both in never-smokers (P = 0.007 for trend) and female never-smokers (P = 0.002 for trend). Our findings suggest that the in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients, especially in females.
    Date: 2013-01
    Relation: International Journal of Cancer. 2013 Jan;132(2):449-458.
    Link to: http://dx.doi.org/10.1002/ijc.27630
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000311383600030
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84869505068
    Appears in Collections:[Chao A. Hsiung] Periodical Articles

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