國家衛生研究院 NHRI:Item 3990099045/6402
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    题名: Major functional transcriptome of an inferred center regulator of an ER(-) breast cancer model system
    作者: Liu, LY;Chang, LY;Kuo, WH;Hwa, HL;Lin, YS;Huang, SF;Chen, CN;Chang, KJ;Hsieh, FJ
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. We identified a STAT3 network in silico showing its ability in predicting its target gene expressions primarily for specific tumor subtype, tumor progression, treatment options and prognostic features. The aberrant expressions of MYC and STAT3 are enriched in triple negatives (TN). They promote histological grade, vascularity, metastasis and tumor anti-apoptotic activities. VEGFA, STAT3, FOXM1 and METAP2 are druggable targets. High levels of METAP2, MMP7, IGF2 and IGF2R are unfavorable prognostic factors. STAT3 is an inferred center regulator at early cancer development predominantly in TN.
    日期: 2012-04
    關聯: Cancer Informatics. 2012 Apr;11:87-111.
    Link to: http://dx.doi.org/10.4137/cin.s8633
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860790969
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