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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6362


    Title: Genome-wide association study of treatment refractory schizophrenia in Han Chinese
    Authors: Liou, YJ;Wang, HH;Lee, MTM;Wang, SC;Chiang, HL;Chen, CC;Lin, CH;Chung, MS;Kuo, CC;Liao, DL;Wu, CK;Liu, CM;Liu, YL;Hwu, HG;Lai, IC;Tsai, SJ;Chen, CH;Liu, HF;Chou, YC;Chen, CH;Chen, YT;Hong, CJ;Wu, JY
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04×10?7) and rs11265461 (P = 1.94×10?7) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94×10?6) and rs230529 (P = 1.74×10?7) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05×10?5) and rs3827219 (P = 1.66×10?5) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87×10?5) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85×10?6). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS.
    Date: 2012-03
    Relation: PLoS ONE. 2012 Mar;7(3):Article number e33598.
    Link to: http://dx.doi.org/10.1371/journal.pone.0033598
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000303894900032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84858982485
    Appears in Collections:[王聲昌] 期刊論文
    [劉玉麗] 期刊論文
    [陳嘉祥(2009-2013)] 期刊論文

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