國家衛生研究院 NHRI:Item 3990099045/6352
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    题名: Rapid quantitative analysis of clarithromycin in rat plasma by UPLC-MS/MS after intravenous injection of the clarithromycin-loaded ultrafine PLGA nanoparticles
    作者: Wang, YJ;Wu, YT;Lin, JY;Chu, CH;Huang, HY;Wang, YC;Chen, JK;Yang, CS
    贡献者: Center for Nanomedicine Research
    摘要: Nanoparticles were designed to encapsulate drugs to alter their pharmacological behaviors, therefore, it is very essential to monitor the pharmacokinetic profile of drug encapsulated in nanoparticles in order to clarify and predict their efficacy and side effects. In this paper, we reported a simple, rapid mu-elution 96-well solid phase extraction (muSPE) method combining with ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for determination of nanoformulated drug in rat plasma. This method presented satisfactory results in terms of sensitivity, precision, accuracy, and recovery, for the first time, of quantitatively analyzing clarithromycin (CLA) in rat plasma after intravenous administration CLA-loaded ultrafine PLGA nanoparticles for pharmacokinetic study. This method has been proved to be fast, reliable and reproducible to accurately analyze drug encapsulated in polymeric nanoparticles sample for a pharmacokinetic study.
    日期: 2012-05-01
    關聯: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2012 May 1;895-896:178-181.
    Link to: http://dx.doi.org/10.1016/j.jchromb.2012.03.022
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1570-0232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000303628700026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860187207
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