國家衛生研究院 NHRI:Item 3990099045/6351
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    题名: A redox-switchable Au8-cluster sensor
    作者: Wu, TH;Hsu, YY;Lin, SY
    贡献者: Center for Nanomedicine Research
    摘要: The proof of concept of a simple sensing platform based on the fl uorescence of agold cluster consisting of eight atoms, which is easily manipulated by reduction andoxidation of a specifi c molecule in the absence of chemical linkers, is demonstrated.Without using any coupling reagents to arrange the distance of the donor–acceptorpair, the fl uorescence of the Au 8 -cluster is immediately switched off in the presenceof 2-pyridinethiol (2-PyT) quencher. Through an upward-curving Stern–Volmerplot, the system shows complex fl uorescence quenching with a combination of staticand dynamic quenching processes. To analyze the static quenching constant ( V ) bya “sphere of action” model, the collisional encounter between the Au 8 -cluster and2-PyT presents a quenching radius ( r ) ≈5.8 nm, which is larger than the sum of theradii of the Au 8 -cluster and 2-PyT. This implies that fl uorescence quenching canoccur even though the Au 8 -cluster and 2-PyT are not very close to each other. Thequenching pathway may be derived from a photoinduced electron-transfer processof the encounter pair between the Au 8 -cluster (as an electron donor) and 2-PyT (asan electron acceptor) to allow effi cient fl uorescence quenching in the absence ofcoupling reagents. Interestingly, the fl uorescence is restored by oxidation of 2-PyTto form the corresponding disulfi de compound and then quenched again after thereduction of the disulfi de. This redox-switchable fl uorescent Au 8 -cluster platform isa novel discovery, and its utility as a promising sensor for detecting H 2 O 2 -generatingenzymatic transformations is demonstrated.
    日期: 2012-08
    關聯: Small. 2012 Jul 9;8(13):2099-2105.
    Link to: http://dx.doi.org/10.1002/smll.201102742
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306011500019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863643100
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