國家衛生研究院 NHRI:Item 3990099045/6319
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6319


    Title: Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
    Authors: Hosgood, HD, 3rd;Wang, WC;Hong, YC;Wang, JC;Chen, K;Chang, IS;Chen, CJ;Lu, D;Yin, Z;Wu, C;Zheng, W;Qian, B;Park, JY;Kim, YH;Chatterjee, N;Chen, Y;Chang, GC;Hsiao, CF;Yeager, M;Tsai, YH;Wei, H;Kim, YT;Wu, W;Zhao, Z;Chow, WH;Zhu, X;Lo, YL;Sung, SW;Chen, KY;Yuenger, J;Kim, JH;Huang, L;Chen, YH;Gao, YT;Huang, MS;Jung, TH;Caporaso, N;Zhao, X;Huan, Z;Yu, D;Kim, CH;Su, WC;Shu, XO;Kim, IS;Bassig, B;Chen, YM;Cha, SI;Tan, W;Chen, H;Yang, TY;Sung, JS;Wang, CL;Li, X;Park, KH;Yu, CJ;Ryu, JS;Xiang, Y;Hutchinson, A;Kim, JS;Cai, Q;Landi, MT;Lee, KM;Hung, JY;Tucker, M;Lin, CC;Ren, Y;Perng, RP;Chen, CY;Jin, L;Chen, KC;Li, YJ;Chiu, YF;Tsai, FY;Yang, PC;Fraumeni, JF, Jr.;Seow, A;Lin, D;Zhou, B;Chanock, S;Hsiung, CA;Rothman, N;Lan, Q
    Contributors: Division of Biostatistics and Bioinformatics;National Institute of Cancer Research;Division of Clinical Trial Statistics
    Abstract: A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 x 10(-12)); however, this association did not achieve genome-wide significance (p </= 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 x 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.
    Date: 2012-07
    Relation: Human Genetics. 2012 Jul;131(7):1197-1203.
    Link to: http://dx.doi.org/10.1007/s00439-012-1144-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-6717&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000305195400018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862757832
    Appears in Collections:[I-Shou Chang] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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