國家衛生研究院 NHRI:Item 3990099045/6311
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    题名: Dosimetric evaluation of nanotargeted 188Re-liposome with the MIRDOSE3 and OLINDA/EXM programs
    其它题名: Dosimetric evaluation of nanotargeted Re-188-liposome with the MIRDOSE3 and OLINDA/EXM programs
    作者: Chang, CH;Chang, YJ;Lee, TW;Ting, G;Chang, KP
    贡献者: National Institute of Cancer Research
    摘要: Objective: The OLINDA/EXM computer code was created as a replacement for the widely used MIRDOSE3 code for radiation dosimetry in nuclear medicine. A dosimetric analysis with these codes was performed to evaluate nanoliposomes as carriers of radionuclides ( 188Re-liposomes) in colon carcinoma-bearing mice. Methods: Pharmacokinetic data for 188Re-N, N-bis (2-mercaptoethyl)-N′, N′-diethylethylenediamine ( 188Re-BMEDA) and 188Re-liposome were obtained for estimation of absorbed doses in normal organs. Radiation dose estimates for normal tissues were calculated using the MIRDOSE3 and OLINDA/EXM programs for a colon carcinoma solid tumor mouse model. Results: Mean absorbed doses derived from 188Re-BMEDA and 188Re-liposome in normal tissues were generally similar as calculated by MIRDOSE3 and OLINDA/EXM programs. One notable exception to this was red marrow, wherein MIRDOSE3 resulted in higher absorbed doses than OLINDA/EXM (1.53- and 1.60-fold for 188Re-BMEDA and 188Re-liposome, respectively). Conclusions: MIRDOSE3 and OLINDA have very similar residence times and organ doses. Bone marrow doses were estimated by designating cortical bone rather than bone marrow as a source organ. The bone marrow doses calculated by MIRDOSE3 are higher than those by OLINDA. If the bone marrow is designated as a source organ, the doses estimated by MIRDOSE3 and OLINDA programs will be very similar.
    日期: 2012-05
    關聯: Annals of Nuclear Medicine. 2012 May;26(5):419-425.
    Link to: http://dx.doi.org/10.1007/s12149-012-0593-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0914-7187&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000305395800006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862812845
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