國家衛生研究院 NHRI:Item 3990099045/6306
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911972      在线人数 : 1057
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6306


    题名: Proteomics investigation reveals apoptosis-associated proteins in aryl hydrocarbon receptor-deficient human lung cells treated with 2,3,7,8-Tetrachlorobenzo-p-Dioxin
    作者: Hsiao, ESL;Chang, YW;Lin, P;Liao, PC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most potent dioxin, binds to aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, which subsequently alters gene expression. Epidemiological studies suggested that exposure to TCDD highly enhanced the risk of pulmonary diseases. In this study, we adopted a comparative proteomic approach using two-dimensional gel electrophoresis (2DE) to identify the differential expression of proteins between TCDD-treated control and AhR-deficient lung adenocarcinoma cells. Fifteen proteins from seventeen differential protein spots were identified that four of which were down-regulated and eleven were up-regulated. Western blotting analysis confirmed differential expression for five identified proteins, including GRB10, YWHAG, HSP27, LGALS1 and ACTB. Further protein-protein interaction network analysis of the identified proteins illustrated that twelve proteins were linked to a network containing caspase-3, p53, MDM2 and Akt/PKB, which is known to be associated with apoptosis pathway. Among the identified proteins, GRB10 may play a critical role to regulate the development of apoptosis in human lung cells by TCDD exposure. According to our study, it is expected to lead to new insights into the apoptosis pathway in lung adenocarcinoma by TCDD exposure.
    日期: 2012-03
    關聯: Journal of Proteomics and Bioinformatics. 2012 Mar;5(1):15-23.
    Link to: http://omicsonline.org/blog/proteomics-investigation-reveals-apoptosis-associated-proteins-in-aryl-hydrocarbon-receptor-deficient-human-lung-cells-treated-with-2378-tetrachlorobenzo-p-dioxin/
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863239611
    显示于类别:[林嬪嬪] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP84857580178.pdf3149KbAdobe PDF710检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈