國家衛生研究院 NHRI:Item 3990099045/6293
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    题名: Heme oxygenase-1 in environmental toxin-induced lung disease
    作者: Wu, ML;Layne, MD;Yet, SF
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Abstract Lung disease is the number three killer in the USA and accounts for one of every six deaths in the US. Furthermore, more than 35 million US populations are now living with a chronic lung disease. Therefore it is of urgent need to develop novel strategies that can protect against the development and progression of lung disease. Inhalation of air pollutants or environmental toxins induces inflammation and oxidative stress in the lung, resulting in tissue damage with subsequent decline in lung function. Heme oxygenase-1 (HO-1) is a stress response protein, which is highly inducible in response to pathological stimulation. Due to the cumulative effects of HO-1 on heme catabolism and the generation of biologically active downstream products, induction of HO-1 might serve as a protective mechanism against oxidative stress and inflammation-induced injury. Accumulating evidences have indicated a protective function of HO-1 against lung injury. This review highlights the roles of HO-1 in lung disease induced by environmental toxins such as cigarette smoke, silica, and asbestos.
    日期: 2012-06
    關聯: Toxicology Mechanisms and Methods. 2012 Jun;22(5):323-329.
    Link to: http://dx.doi.org/10.3109/15376516.2012.666685
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1537-6516&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000303835200002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860850570
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