國家衛生研究院 NHRI:Item 3990099045/6234
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    題名: The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities
    作者: Shih, HJ;Chu, KL;Wu, MH;Wu, PH;Chang, WW;Chu, JS;Wang, LH;Takeuchi, H;Ouchi, T;Hsu, HL
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Centrosome amplification and chromosome abnormality are frequently identified in neoplasia and tumorigenesis. However, the mechanisms underlying these defects remain unclear. We here identify that MCT-1 is a centrosomal oncoprotein involved in mitosis. Knockdown of MCT-1 protein results in intercellular bridging, chromosome mis-congregation, cytokinesis delay, and mitotic death. Introduction of MCT-1 oncogene into the p53 deficient cells (MCT-1-p53), the mitotic checkpoint kinases and proteins are deregulated synergistically. These biochemical alterations are accompanied with increased frequencies of cytokinesis failure, multi-nucleation, and centrosome amplification in subsequent cell cycle. As a result, the incidences of polyploidy and aneuploidy are progressively induced by prolonged cell cultivation or further promoted by sustained spindle damage on MCT-1-p53 background. These data show that the oncoprotein perturbs centrosome structure and mitotic progression, which provide the molecular aspect of chromsomal abnormality in vitro and the information for understanding the stepwise progression of tumors under oncogenic stress.
    日期: 2012-03-01
    關聯: Cell Cycle. 2012 Mar 1;11(5):934-952.
    Link to: http://dx.doi.org/10.4161/cc.11.5.19452
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1538-4101&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000300989700023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863231362
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