國家衛生研究院 NHRI:Item 3990099045/6219
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    题名: Statin use and the risk of colorectal cancer: A population-based case-control study
    作者: Cheng, MH;Chiu, HF;Ho, SC;Tsai, SS;Wu, TN;Yang, CY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: AIM: T0 investigate whether the use of statins is associated with colorectal cancer risk. METHODS: We conducted a population-based case-control study in Taiwan. Data were retrospectively collected from the Taiwan National Health Insurance Research Database. Cases consisted ofall patients who were aged 50 years and older and had a first-time diagnosis ofcolorectal cancer between the period 2005 and 2008. The controls were matched to cases by age, sex, and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multiple logistic regression. RESULTS: We examined 1156 colorectal cancer cases and 4624 controls. The unadjusted ORs for any statin prescription was 1.10 (95% CI = 0.94-1.30) and the adjusted OR was 1.09 (95% CI =0.91-1.30). When statin use was categorized by cumulative dose, the adjusted ORs were 0.99 (95% CI 77w=0.78-1.27) for the group with cumulative statin use below105 defined daily doses (DDDs); 1.07(95% CI7w=0.78-1.49) for the group with cumulative statin use between 106 and 298.66 DDDs; and 1.30 (95% CI0.96-1.75) for the group with cumulative statin use of298.66 DDDs or more compared with nonusers. CONCLUSION: This study does not provide support for a protective effect ofstatins against colorectal cancer.
    日期: 2011-12-21
    關聯: World Journal of Gastroenterology. 2011 Dec 21;17(47):5197-5202.
    Link to: http://dx.doi.org/10.3748/wjg.v17.i47.5197
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1007-9327&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000298549600009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=83755228779
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