國家衛生研究院 NHRI:Item 3990099045/6148
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    题名: Association of betel nut chewing with chronic kidney disease: A retrospective 7-year study in Taiwan
    作者: Hsu, YH;Liu, WH;Chen, W;Kuo, YC;Hsiao, CY;Hung, PH;Jong, IC;Chiang, PC;Hsu, CC
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Aim: Only few studies have reported that betel nut (BN) chewing is independently associated with chronic kidney disease (CKD); however, the sample size was relatively small. This study was to explore further the association between BN chewing and CKD using a larger case series. Methods: We retrospectively reviewed the records of a health check-up program from 2003 to 2009. Laboratory tests, medical history and status of cigarette smoking, alcohol drinking and BN chewing were compared between CKD and non-CKD groups. We checked interaction effects between BN chewing and all other covariates, and conducted multivariate logistic regression analysis to explore the risk of CKD with BN chewing. Results: A total of 27 482 participants (15 491 females and 11 991 males, mean age 58.02 +/- 11.85 years) were included in the study, of whom 4519 (16.4%) had CKD and 1608 (5.9%) chewed BN. CKD prevalence in the chewers was higher than in the non-chewers in all age groups per decade. BN chewing was significantly associated with CKD in overall subjects (odds ratio (OR) = 1.23, P = 0.027) and also in the male (OR = 1.23, P = 0.035), non-drinking (OR = 1.62, P = 0.000), non-diabetic (OR = 1.27, P = 0.021), and non-proteinuric groups (OR = 1.30, P = 0.013). This relationship was insignificant in female, drinking, diabetic and proteinuric groups. Conclusion: The association between BN chewing and CKD seemed conditional on demographics, health behaviours, and underlying co-morbidities. This association should be interpreted cautiously.
    日期: 2011-11
    關聯: Nephrology. 2011 Nov;16(8):751-757.
    Link to: http://dx.doi.org/10.1111/j.1440-1797.2011.01489.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1320-5358&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000297414300012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84055211977
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