國家衛生研究院 NHRI:Item 3990099045/6131
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    题名: Targeting cathepsin S induces tumor cell autophagy via the EGFR-Erk signaling pathway
    作者: Chen, KL;Chang, WS;Cheung, CH;Lin, CC;Huang, CC;Yang, YN;Kuo, CP;Kuo, CC;Chang, YH;Liu, KJ;Wu, CM;Chang, JY
    贡献者: National Institute of Cancer Research
    摘要: Cathepsin S is a cellular cysteine protease, which is frequently over-expressed in human cancer cells and plays important role in tumor metastasis. However, the role of cathepsin S in regulating cancer cell survival and death remains undefined. The aim of this study was to determine whether targeting cathepsin S could induce autophagy/apoptosis in cancer cells. In this study, we demonstrated that targeting cathepsin S by either specific small molecular inhibitors or cathepsin S siRNA induced autophagy and subsequent apoptosis in human cancer cells, and the induction of autophagy was dependent on the phosphorylation of EGFR and activation of the EGFR-related ERK/MAPK-signaling pathway. In conclusion, the current study reveals that cathepsin S plays an important role in the regulation of cell autophagy through interference with the EGFR-ERK/MAPK-signaling pathway.
    日期: 2012-04
    關聯: Cancer Letters. 2012 Apr;317(1):89-98.
    Link to: http://dx.doi.org/10.1016/j.canlet.2011.11.015
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000301698900012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84856323422
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