國家衛生研究院 NHRI:Item 3990099045/6126
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6126


    Title: Overexpression of alpha-enolase correlates with poor survival in canine mammary carcinoma
    Other Titles: Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma
    Authors: Chu, PY;Hsu, NC;Liao, AT;Shih, NY;Hou, MF;Liu, CH
    Contributors: National Institute of Cancer Research
    Abstract: Background: alpha-Enolase (ENO1) is a key glycolytic enzyme implicated in the development of many human cancers including breast cancer. Increased expression of ENO1 has recently been reported in estrogen (ER) positive human breast cancer patients. The present study examined the expression of ENO1 and assessed its significance in canine mammary carcinoma. Results: Immunohistochemical staining was employed to investigate the expression of ENO1 in 82 cases of canine mammary tumor (32 benign tumors and 50 carcinomas). Quantification of immunohistochemistry was carried out using Quick score and the results showed cytoplasmic ENO1 overexpression in 9 of the 50 carcinomas (18%). Overexpression of ENO1 correlated significantly with shorter cause-specific survival (P = 0.019), but was not associated with ER positivity in canine mammary carcinoma. Conclusions: Our findings suggest that overexpression of ENO1 may be used as a prognostic marker for poor outcome in canine mammary carcinoma.
    Date: 2011-10-21
    Relation: BMC Veterinary Research. 2011 Oct 21;7:Article Number 62.
    Link to: http://dx.doi.org/10.1186/1746-6148-7-62
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1746-6148&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000296694100001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80054757041
    Appears in Collections:[Neng-Yao Shih] Periodical Articles

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